Dr. Todd K. Rosengart: Selected Publications

Amano H, Hackett NR, Kaner RJ, Whitlock P, Rosengart TK, Crystal RG. Alteration of splicing signals in a genomic/cDNA hybrid VEGF gene to modify the ratio of expressed VEGF isoforms enhances safety of angiogenic gene therapy. Mol Ther 2005;12:716-24.

Amano H, Hackett NR, Rosengart TK, Whitlock P, Crystal RG. Modification of VEGF splicing to express greater amounts of VEGF189 results in equipotent angiogenic gene therapy but a better safety profile [abstract]. Mol Ther 2003;7:S241-2.

Baumgartner WA, Burrows S, del Nido PJ, Gardner TJ, Goldberg S, Gorman RC, Letsou GV, Mascette A, Michler RE, Puskas JD, Rose EA, Rosengart TK, Sellke FW, Shumway SJ, Wilke N; National Heart, Lung, and Blood Institute Working Group on Future Direction in Cardiac Surgery. Recommendations of the National Heart, Lung, and Blood Institute Working Group on Future Direction in Cardiac Surgery. Circulation 2005;111:3007-13.

Ben-Gary H, McKinney RL, Rosengart TK, Lesser ML, Crystal RG. Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes. Mol Ther 2002;6:287-97.

Boyd WC, Rosengart TK, Hartman GS. Isolated left ventricular diverticulum in an adult. J Cardiothorac Vasc Anesth 1999;13:468-70.

Caso G, Rosengart TK, Patejunas G. Reduced tumor growth in mice lacking Egr-1 [abstract]. FASEB J 2008;22:lb603.

Crystal RG, Harvey BG, Wisnivesky JP, O'Donoghue KA, Chu KW, Maroni J, Muscat JC, Pippo AL, Wright CE, Kaner RJ, Leopold PL, Kessler PD, Rasmussen HS, Rosengart TK, et al. Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions. Hum Gene Ther 2002;13:65-100.

Dang NC, Aboodi MS, Sakaguchi T, Wasserman HS, Argenziano M, Cosgrove DM, Rosengart TK, Feldman T, Block PC, Oz MC. Surgical revision after percutaneous mitral valve repair with a clip: initial multicenter experience. Ann Thorac Surg 2005;80:2338-42.

DeBois WJ, Rosengart TK. Retrograde autologous priming reduces blood use. Ann Thorac Surg 1998;66:987-8.

Deutsch E, Tarazona N, Sanborn TA, Martin JL, Lee LY, Hackett N, El-Sawy T, Blanco I, Fromkin KR, Rosengart TK, et al. Patterns of in-vivo gene expression related to regional myocardial delivery [abstract]. J Am Coll Cardiol 2000;35:6A.

Fang WC, Helm RE, Krieger KH, Rosengart TK, DeBois WJ, Sason C, et al. Impact of minimum hematocrit during cardiopulmonary bypass on mortality in patients undergoing coronary artery surgery. Circulation 1997;96:II-194-9.

Frank MW, Rosengart TK. Robotic cardiac surgery. New Surgery 2001;1:127-9.

Hackett NR, El Sawy T, Lee LY, Silva I, O'Leary J, Rosengart TK, et al. Use of quantitative TaqMan real-time PCR to track the time-dependent distribution of gene transfer vectors in vivo. Mol Ther 2000;2:649-56.

Hamawy AH, Lee LY, Crystal RG, Rosengart TK. Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization. Curr Opin Cardiol 1999;14:515-22.

Hamawy AH, Lee LY, Samy SA, Polce DR, Szulc M, Vazquez M, Rosengart TK. Transmyocardial laser revascularization dose response: enhanced perfusion in a porcine ischemia model as a function of channel density. Ann Thorac Surg 2001;72:817-22.

Hamawy AH, Samy SA, Isom OW, Crystal RG, Rosengart TK. Myocardial administration of an adenovirus vector coding for the angiogenesis mediator vascular endothelial growth factor 121 helps to improve myocardial contractility in heart failure [abstract]. Mol Ther 2000;1:S257.

Harvey BG, Hackett NR, El-Sawy T, Rosengart TK, Hirschowitz EA, Lieberman MD, et al. Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs. J Virol 1999;73:6729-42.

Harvey BG, Maroni J, O'Donoghue KA, Chu KW, Muscat JC, Pippo AL, Wright CE, Hollmann C, Wisnivesky KP, Kessler PD, Rasmussen HS, Rosengart TK, et al. Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions. Hum Gene Ther 2002;13:15-63.

Helm RE, Rosengart TK, Gomez M, Klemperer JD, DeBois WJ, Velasco F, et al. Comprehensive multimodality blood conservation: 100 consecutive CABG operations without transfusion. Ann Thorac Surg 1998;65:125-36.

Jeremias A, Kaul S, Rosengart TK, Gruberg L, Brown DL. The impact of revascularization on mortality in patients with nonacute coronary artery disease. Am J Med 2009;122:152-61.

Klemperer JD, Ko W, Krieger KH, Connolly M, Rosengart TK, Altorki NK, et al. Cardiac operations in patients with cirrhosis. Ann Thorac Surg 1998;65:85-7.

Korst RJ, Rosengart TK. Operative strategies for resection of pulmonary sarcomas extending into the left atrium. Ann Thorac Surg 1999;67:1165-7.

Landesberg LJ, Ramalingam R, Lee K, Rosengart TK, Crystal RG. Upregulation of transcription factors in lung in the early phase of postpneumonectomy lung growth. Am J Physiol Lung Cell Mol Physiol 2001;281:L1138-49.

Lee LY, Lee KT, Crystal RG, Rosengart TK. Biological revascularization using adenovirus coding for vascular endothelial growth factor 121. In: Kornowski R, Epstein SE, Leon MB, editors. Handbook of Myocardial Revascularization. London: Dunitz, 1999.

Lee LY, O'Hara MF, Finnin EB, Hachamovitch R, Szulc M, Kligfield PD, Okim PM, Isom OW, Rosengart TK. Transymyocardial laser revascularization with excimer laser: clinical results at 1 year. Ann Thorac Surg 2000;70:498-503.

Lee LY, Patel SR, Hackett NR, Mack CA, Polce DR, El-Sawy T, Hachamovitch R, Zanzonico P, Sanborn TA, Parikh M, Isom OW, Crystal RG, Rosengart TK. Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121. Ann Thorac Surg 2000;69:14-24.

Lee LY, Rahman GF, Lee KT, Hackett NR, Isom OW, Crystal RG, Rosengart TK. Global perfusion vs regional administration strategies for myocardial gene therapy [abstract]. J Am Coll Cardiol 2000;35(2 Suppl):279A.

Lee LY, Rahman GF, Zhou X, Polce DR, Yin X, Hackett NR, Isom OW, Crystal RG, Rosengart TK. Long term (greater than 1 year) high level myocardial transgene expression with an adeno-associated virus [abstract]. J Am Coll Cardiol 2000;35(2 Suppl):278A-9A.

Lee LY, Rosengart TK. Transmyocardial laser revascularization and angiogenesis: the potential for therapeutic benefit. Semin Thorac Cardiovasc Surg 1999;11:29-35.

Lee LY, Zhou X, Polce DR, Patel SR, Thakker GD, Narumi K, Crystal RG, Rosengart TK. Exogenous control of cardiac gene therapy: evidence of regulated myocardial transgene expression after adenovirus and adeno-associated virus transfer of expression cassettes containing corticosteroid response element promoters. J Thorac Cardiovasc Surg 1999;118:26-35.

Leotta E, Patejunas G, Murphy G, Szokol J, McGregor L, Hamawy A, Winchester DP, Hackett N, Crystal R, Rosengart TK. Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of congestive heart failure. J Thorac Cardiovasc Surg 2002;123:1101-13.

Mack CA, Magovern CJ, Budenbender KT, Patel SR, Schwartz EA, Zanzonico P, Ferris B, Sanborn T, Isom P, Ferris B, Crystal RG, Rosengart TK. Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusions. J Vasc Surg 1998;27:699-709.

Mack CA, Magovern CJ, Hahn RT, Sanborn T, Lanning L, Ko W, Isom OW, Rosengart TK. Channel patency and neovascularization after transmyocardial revascularization using an excimer laser: results and comparisons to nonlased channels. Circulation 1997;96:II-65-9.

Mack CA, Patel SR, Rosengart TK. Myocardial angiogenesis as a possible mechanism for TMLR efficacy. J Clin Laser Med Surg 1997;15:275-9.

Mack CA, Patel SR, Schwarz EA, Zanzonico P, Hahn RT, Ilercil A, Devereux RB, Goldsmith SJ, Goldsmith SJ, Christian TF, Sanborn TA, Kovesdi I, Hackett N, Isom OW, Crystal RG, Rosengart TK. Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart. J Thorac Cardiovasc Surg 1998;115:168-77.

Mack CA, Song WR, Carpenter H, Wickham TJ, Kovesdi I, Harvey BG, Magovern CJ, Isom OW, Rosengart TK, et al. Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype. Hum Gene Ther 1997;8:99-109.

Magovern CJ, Mack CA, Zhang J, Rosengart TK, Isom OW, Crystal RG. Regional angiogenesis induced in nonischemic tissue by an adenoviral vector expressing vascular endothelial growth factor. Hum Gene Ther 1997;8:215-27.

McCaffrey TA, Fu C, Du B, Eksinar S, Kent KC, Bush H Jr, Krieger K, Rosengart TK. High-level expression of egr-1 and egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest 2000;105:653-62.

Mueller RL, Rosengart TK, Isom OW. The history of surgery for ischemic heart disease. Ann Thorac Surg 1997;63:869-78.

Murphy GS, Szokol JW, Marymount JH, Avram MJ, Vender JS, Rosengart TK. Impact of shorter-acting neuromuscular blocking agents on fast-track recovery of the cardiac surgical patient. Anesthesiology 2002;96:600-6.

Murphy GS, Szokol JW, Marymount JH, Vender JS, Avram MJ, Rosengart TK, Alwawi EA. Recovery of neuromuscular function after cardiac surgery: pancuronium versus rocuronium. Anesth Analg 2003;96:1301-7.

Nayak L, Rosengart TK. Gene therapy for heart failure. Semin Thorac Cardiovasc Surg 2005;17:343-7.

Patel SR, Lee LY, Mack CA, Polce DR, El-Sawy T, Hackett NR, Ilercil A, Jones EC, Hahn RT, Isom OW, Rosengart TK, et al. Safety of direct myocardial administration of an adenovirus vector encoding vascular endothelial growth factor 121. Hum Gene Ther 1999;18:1331-48.

Rajamannan NM, Nealis TB, Subramaniam M, Pandya S, Stock SR, Ignatiev CI, Sebo TJ, Rosengart TK, Edwards WD, McCarthy PM, Bonow RO, Spelsberg TC. Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation. Circulation 2005;111:3296-301.

Retuerto MA, Beckmann JT, Carbray J, Patejunas G, Sarateanu S, Kane BJ, Smulevitz B, McPherson DD, Rosengart TK. Angiogenic pretreatment to enhance myocardial function after cellular cardiomyoplasty with skeletal myoblasts. J Thorac Cardiovasc Surg 2007;133:478-484.

Retuerto MA, Schlach P, Patejunas G, Carbray J, Liu N, Esser K, Crystal RG, Rosengart TK. Angiogenic pretreatment improves the efficacy of cellular cardiomyoplasty performed with fetal cardiomyocyte implantation. J Thorac Cardiovasc Surg 2004;127:1041-50.

Rosengart TK. Anticoagulation self-testing after heart valve replacement. J Heart Valve Dis 2002;11:S61-5.

Rosengart TK. Blood conservation for open heart surgery. In: Franco K, Verrier ED, editors. Advanced Therapy in Cardiac Surgery. 2nd ed. Hamilton, Ontario: Decker, 2003: 37-46.

Rosengart TK. Book review: Adult Cardiac Surgery. N Engl J Med 2004;350:1162.

Rosengart TK. Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization. In: Factor PH, editor. Gene Therapy for Acute and Acquired Diseases. Norwell, MA: Kluwer, 2000.

Rosengart TK. Commentary: Gene therapy: true promise fulfilled. Nature 2003;10:1.

Rosengart TK. Introduction: the era of cardiac biointerventions. In: Rosengart TK, Cox, JL, editors. Seminars in Thoracic and Cardiothoracic Surgery. Orlando, FL: Saunders, 2003: 217-21.

Rosengart TK. Invited commentary [re: cognitive outcomes five years after not undergoing coronary artery bypass graft surgery]. Ann Thorac Surg 2008;85:64.

Rosengart TK. Outcome analysis of 245 CarboMedics and St. Jude valves implanted at the same institution (letter to editor). Ann Thorac Surg 1999;67:1543.

Rosengart TK. Transmyocardial laser revascularization—a technique in evolution. J Clin Laser Med Surg 1997;15:299-300.

Rosengart TK, Budenbender KT, Duenas M, Mack CA, Zhang QX, Isom OW. Therapeutic angiogenesis: a comparative study of the angiogenic potential of acidic fibroblast growth factor and heparin. J Vasc Surg 1997;26:302-12.

Rosengart TK, Chedrawy EG, Patejunas, G, Retuarto, M. Vascular endothelial growth factors before cells. J Thorac Cardiovasc Surg 2005;129:696.

Rosengart TK, Cohn RH. Transmyocardial Revascularization. In: Yang S, Cameron D, editors. Current Therapy in Thoracic and Cardiovascular Surgery. Philadelphia: Elsevier, 2004: 681-2.

Rosengart TK, DeBois W. Transfusion alternatives for cardiac surgery. Transfusion Medicine and Alternatives to Blood Transfusion. Paris: Imprimeries de Champagne, 2000; 454-60.

Rosengart TK, de Bois W, Chedrawy E, Vukovic M. Adult heart disease. In: Norton JA, Barie PS, Bollinger RR, Chang AE, Lowry SF, Mulvihill SJ, et al., editors. Surgery: Basic Science and Clinical Evidence. 2nd ed. New York: Springer, 2008: 1621-68.

Rosengart TK, DeBois W, Francalania NA. Adult heart disease. In: Norton JA, Bollinger AE, Chang AE, et al, editors. Essential Practice of Surgery. New York: Springer-Verlag, 2003: 567-85.

Rosengart TK, DeBois W, O'Hara M, Helm R, Gomez M, Lang SJ, et al. Retrograde autologous priming for cardiopulmonary bypass: a safe and effective means of decreasing hemodilution and transfusion requirements. J Thorac Cardiovasc Surg 1998;115:426-39.

Rosengart TK, Feldman T, Borger MA, Vassiliades TA Jr, Gillinov AM, Hoercher KJ, Vahanian A, Bonow RO, O'Neill W. Percutaneous and minimally invasive valve procedures. A scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplinary Working Group, and Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 2008;117:1750-67.

Rosengart TK, Finnin EB. Open heart surgery in the "oldest old": results from a consecutive series of 100 patients 85 years and older [abstract]. Circulation 2000;102:II-556.

Rosengart TK, Finnin EB, Hudgens SA, Hahn EA, Curran RD, Votapka TV, Frank MW, et al. Predictors of saphenous vein graft patency: a risk assessment based on a longitudinal analysis of 100 consecutive post-coronary bypass angiographic studies [abstract]. J Am Coll Cardiol 2003;41:499A.

Rosengart TK, Finnin EB, Kim DY, Samy SA, Tanhehco Y, Ko W, et al. Open heart surgery in the elderly: results from a consecutive series of 100 patients aged 85 years or older. Am J Med 2002;112:143-7.

Rosengart TK, Hamawy AH, Leotta E, McGregor L, Sanborn TA, Isom WO, et al. Coadministration of adenovirus encoding for VEGF 121 and transmyocardial revascularization with an excimer laser increase survival in a double ameroid model of severe myocardial ischemia [abstract]. Circulation 2000;102:II-10.

Rosengart TK, Hamawy AH, Samy SA, Leotta E, McGregor L, Sanborn TA, et al. Adenovirus encoding for vascular endothelial growth factor 121 preserves myocardial response to inotropic stimulation and improves contractility in a pacing model of ischemic cardiomyopathy [abstract]. Circulation 2000;102:II-453.

Rosengart TK, Helm RE, DeBois WJ, Garcia N, Krieger KH, Isom OW. Open heart operations without transfusion using a multimodality blood conservation strategy in 50 Jehovah's Witness patients: implications for a "bloodless" surgical technique. J Am Coll Surg 1997;184:618-29.

Rosengart TK, Hillebrand K. Gene therapy for coronary artery disease. Adv Card Surg 2001;13:107-11.

Rosengart TK, Lang S, Helm R, Friedman D. Open heart surgery in the pediatric Jehovah's Witness population: no longer "Russian roulette." Pediatr Cardiol 1997;18:245-6.

Rosengart TK, Lee LY, Patel SR, Kligfield PD, Okin PM, Hackett NR, et al. Six-month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA. Ann Surg 1999;230:466-72.

Rosengart TK, Lee LY, Patel SR, Sanborn TA, Parikh M, Bergman GW, et al. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation 1999;100:468-74.

Rosengart TK, O'Hara M, Lang SJ, Ko W, Altorki N, Krieger KH, et al. Outcome analysis of 245 CarboMedics and St. Jude valves implanted at the same institution. Ann Thorac Surg 1998;66:1684-91.

Rosengart TK, Patel SR, Crystal RG. Therapeutic angiogenesis: protein and gene therapy delivery strategies. J Cardiovasc Risk 1999;6:29-40.

Rosengart TK, Sweet J, Finnin EB, Wolfe P, Cashy J, Hahn E, Marymont J, Sanborn T. Neurocognitive functioning in patients undergoing coronary artery bypass graft surgery or percutaneous coronary intervention: evidence of impairment before intervention compared with normal controls. Ann Thorac Surg 2005;80:1327-35.

Rosengart TK, Sweet JJ, Finnin E, Wolfe P, Cashy J, Hahn E, Marymont J,Sanborn T. Stable cognition after coronary artery bypass grafting: comparisons with percutaneous intervention and normal controls. Ann Thorac Surg 2006;82:597-607.

Sanborn TA, Hackett NR, Lee LY, Blanco I, Tarazona N, Deutsch E, Rosengart TK, et al. Regional intramyocardial vascular endothelial growth factor (VEGF) gene transfer and expression using a fluoroscopically guided catheter-based technique [abstract]. J Am Coll Cardiol 2000;35(2 Suppl):74A.

Sanborn TA, Hackett NR, Lee LY, El-Sawy T, Blanco I, Tarzona N, Deutsch E, Crystal R, Rosengart TK. Percutaneous endocardial transfer and expression of genes to the myocardium utilizing fluoroscopic guidance. Catheter Cardiovasc Interv 2001;52:260-6.

Sarateanu CS, Retuerto MA, Beckmann JT, McGregor L, Carbray J, Patejunas G, Nayak L, Milbrandt J, Rosengart TK. An Egr-1 master switch for arteriogenesis: studies in Egr-1 homozygous negative and wild-type animals. J Thorac Cardiovasc Surg 2006;131:138-45.

Schalch P, Patejunas G, Sarateanu CS, Retuerto M, Millbrandt J, Thakker G, Kim D, Carbray J, Crystal RG, Rosengart TK. Homozygous deletion of EGR-1 results in critical limb ischemia following vascular ligation: evidence for a central role of EGR-1 in vascular homeostasis. J Thorac Cardiovasc Surg 2004;128:595-601.

Schalch P, Rahman GF, Goldschmidt RA, Carbray J, Retuerto MA, Kim D, Esser K, Crystal RG, Rosengart TK. Adenoviral mediated transfer of vascular endothelial growth factor 121 improves exercise tolerance in the non-ischemic heart [abstract]. Mol Ther 2003;7:S244-5.

Schlach P, Rahman GF, Patejunas G, Goldschmidt RA, Carbray J, Retuerto MA, Kim D, Esser K, Crystal RG, Rosengart TK. Adenoviral-mediated transfer of vascualr endothelial growth factor 121 cDNA enhances myocardial perfusion and exercise performance in the nonischemic state. J Thorac Cardiovasc Surg 2004;127:535-40.

Schalch P, Ramchandran R, Kim DY, Patejunas G, Retuerto MA, Milbrandt JD, Crystal RG, Rosengart TK. The early growth response-1 (EGR-1) gene is critical to reperfusion following acute vascular obstruction: results from a knockout mouse ischemia model [abstract]. J Am Coll Cardiol 2003;41:279A.

Simons M, Bonow RO, Chronos NA, Cohen DJ, Giordano FJ, Hammond HK, Laham RJ, Li W, Pike M, Selke FW, Stegmann TJ, Udelson JE, Rosengart TK. Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary. Circulation 2000;102:E73-86.

Sweet JJ, Finnin E, Wolfe PL, Beaumont JL, Hahn E, Marymont J, Sanborn T, Rosengart TK. Absence of cognitive decline one year after coronary bypass surgery. Ann Thorac Surg 2008:85:1571-8.

Syed JS, Sanborn TA, Rosengart TK. Therapeutic angiogenesis: a biologic bypass. Cardiology 2004;101:131-43.

Szokol JW, Murphy GS, Stagl RD, Rosengart TK. Enlarged abnormal anatomic structure adjacent to the aortic valve. J Cardiothorac Vasc Anesth 2002;16:125-6.

Thakker GD, Hajjar DP, Muller WA, Rosengart TK. The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling. J Biol Chem 1999;274:10002-7.

Upadhyay A, Maurer J, Turner J, Tiszenkel H, Rosengart T. Elective bedside tracheostomy in the intensive care unit. J Am Coll Surg 1996;183:51-5.

Whitlock P, Hackett NR, Leopold PL, Rosengart TK, Crystal RG. A novel adenovirus vector producing multiple isoforms of VEGF reverses hind limb ischemia in the mouse at lower doses than equivalent vectors expressing only a single VEGF isoform [abstract]. Mol Ther 2003;7:S330.

Whitlock PR, Hackett NR, Leopold PL, Rosengart TK, Crystal RG. Adenovirus-mediated transfer of a minigene expressing multiple isoforms of VEGF is more effective at inducing angiogenesis than comparable vectors expressing individual VEGF cDNAs. Mol Ther 2004;9:67-75.

Yee AI, Rosengart TK. Angiogenesis and gene therapy for the treatment of coronary artery disease. In: Franco K, Verrier E, editors. Advanced Therapy in Cardiac Surgery. 2nd ed. Hamilton, Ontario: Decker, 2003: 138-46.

Zhang QX, Duenas M, Rosengart T. Effect of tumor necrosis factor-alpha on a cell line transformed by a secreted form of human fibroblast growth factor-1 gene and on its parental cell line. Cancer Lett 1995;89:49-54.

Zhang QX, Magovern CJ, Mack CA, Budenbender KT, Ko W, Rosengart TK. Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis. J Surg Res 1997;67:147-54.

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